Selective leptin resistance revisited
نویسندگان
چکیده
منابع مشابه
Selective leptin resistance revisited.
In addition to effects on appetite and metabolism, leptin influences many neuroendocrine and physiological systems, including the sympathetic nervous system. Building on my Carl Ludwig Lecture of the American Physiological Society, I review the sympathetic and cardiovascular actions of leptin. The review focuses on a critical analysis of the concept of selective leptin resistance (SLR) and the ...
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Leptin is an adipocyte-derived hormone that plays a key role in the regulation of body weight through its actions on appetite and metabolism. Leptin also increases sympathetic nerve activity (SNA) and blood pressure. We tested the hypothesis that diet-induced obesity is associated with resistance to the metabolic actions of leptin but preservation of its renal SNA and arterial pressure effects,...
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1 MD, General Clinical Research Center and Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa. Correspondência para: Marcelo Correia, MSc, MD, PhD, Department of Clinical Medicine. State University of Rio de Janeiro. Av. Lineu de Paula Machado, 850 – 22470-040 – Rio de Janeiro, RJ. E-mail: [email protected] Recebido: 5/5/2008 Aceito: 28/5/20...
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The identification of spontaneous mutations in the leptin- and leptin receptor (ObR)-encoding ob and db gene, respectively, opened up a new field in obesity research. Leptin, an adipocyte-derived hormone, mirrors the body's fat stores and thereby informs the brain about the body's energy status. In the hypothalamus, leptin triggers specific neuronal subpopulations, like POMC and AgRP/NPY neuron...
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The adipose tissue-derived hormone leptin acts via its receptor (LRb) in the brain to regulate energy balance and neuroendocrine function. LRb signaling via STAT3 and a number of other pathways is required for the totality of leptin action. The failure of elevated leptin levels to suppress feeding and mediate weight loss in common forms of obesity defines a state of so-called leptin resistance....
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2013
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00180.2013